#4202 FLUID OVERLOAD AT THE BEGINNING OF PERITONEAL DIALYSIS: A CROSS-SECTIONAL STUDY TO DETERMINE ITS ASSOCIATION WITH SERUM BIOMARKERS

Abstract Background and Aims Volume management in peritoneal dialysis (PD) patients is of major importance as fluid overload has been associated with cardiovascular non-cardiovascular morbidity mortality. Clinical examination itself a poor diagnostic accuracy for minor deviations from normohydration, highlighting the need additional tools. The aim this study was to evaluate association between serum biomarkers (CA-125 NT-proBNP) volume status, evaluated by clinical bioimpedance analysis, at initiation PD technique. Method Single-center cross-sectional including that started technique 2017 2022. Demographic data were collected electronic records. Parameters examination, biomarkers, adequacy. Results A total 79 (51 male) included mean age 57±15 years. All them CAPD 52% under icodextrin. Hypertension, disease diabetes present 94%, 51% 34%, respectively. great majority renin-angiotensin-aldosterone system inhibitors (91%), beta-blockers (48%) diuretic therapy (94%). Baseline PET showed 77% high or high-average transporters. Mean weekly Kt/V 2.4±15. residual renal function (RRF) diuresis 6.7±15 mL/min/1.73 m2 1.6±0.8 L (4% anuric), respectively, 11% had ultrafiltration failure. Median nPCR 0.9 g/Kg/day (IQR 0.3). NT-proBNP CA-125 1337 pg/mL 3401) 14.6 U/mL 17.6), positively overhydration (OH >2 L) (r = 0.31; p 0.009), 0.28; 0.01) icodextrin use (p 0.002). It negatively -0.35; 0.003), RRF -0.36; 0.002), test (UFT) 0.003) -0.28; 0.001). higher > 3.6 L), D/P creatinine 0.3; 0.004) -0.3; 0.01), UFT -0.25; 0.03) -0.23; 0.04). still multivariable adjusted diabetes, use, 0.024). Conclusion Serum seem be good markers baseline. They also worse dialytic efficacy ultrafiltration, lower an early use. Malnourished CA-125. Early effective hydration may improve outcomes, allowing personalized prescription nutritional support.